The control of healthcare costs as well as the means for this achievement is a multifaceted problem for governments all over the world. The aim of this work is to determine the areas of activity of 16 Greek Public Hospital Units (H.U.), which present problems regarding their performance and suggest sufficient solutions. The method used for this study was quantitative analysis methods and especially the application of Data Envelopment Analysis (D.E.A.) in the 16 H.U. Results : According to the results, information was provided to their managers, concerning: (i) the assessment of the sources of management pathogenesis per H.U., (ii) the essential information about the mapping out of 'the best utilization of financial resources' by H.U. administrations and (iii) the evaluation criteria of H.U.' administrations. The derived information provided basic guidelines about the creation of an appropriate policy plan per H.U., which should be applied by their administrations in combination with a set of measures that need to be undertaken in order to promote efficiency.